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Collectively, in animal studies, the location of spexin-producing neurons is often in close proximity to the serotonergic (5-HT) neuron fibers, which complements theories on SPX-CRH-5-HT inter-actions and thus a possible effect of SPX on mood and behavior

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Surprisingly, according to the previous system, the obesity-induced oxidative stress should lead to ferroptosis of traditional T cells, but the number of CD4 + T cells with pro-inflammatory effects and CD8 + T cells has been found to increased significantly (152)